Babies born in the United States have a higher chance of death than babies born in more than 50 other countries in the world. Harnessing lessons-learned from successful improvement initiatives can help hospitals and state health systems address this alarming statistic. Here, pioneer for improvement Deborah Campbell, MD, FAAP, shares strategies and lessons-learned from three successful improvement efforts: improving nutrition protocols for preterm infants; spreading safe sleep messages to reduce infant deaths; and testing strategies to lower rates of maternal hemorrhage, and related mortality and morbidity.