Hypophosphatasia (HPP) is a rare and potentially life-threatening disorder that can begin prenatally and adversely affects teeth and bone development. While the severity of HPP varies, with some cases only affecting dental development, children born with more severe forms of HPP have soft or weakened bones that can cause skelatol deformities, fractures, pain and, in the most severe cases, death. It is estimated that severe forms of HPP occur in one out of every 100,000 live births.